diff --git a/.ci/ansible/Containerfile.j2 b/.ci/ansible/Containerfile.j2
index 13b5ff05e3..69c62ba04e 100644
--- a/.ci/ansible/Containerfile.j2
+++ b/.ci/ansible/Containerfile.j2
@@ -9,7 +9,7 @@ ADD ./{{ plugin_name }}/{{ plugin_name | replace("-", "_") }}/app/webserver_snip
 ADD ./{{ item.origin }} {{ item.destination }}
 {%- endfor %}
 
-# This MUST be the ONLY call to pip install in inside the container.
+# This MUST be the ONLY package install inside the container.
 RUN --mount=type=cache,target=/root/.cache/uv uv pip install --upgrade setuptools wheel && \
   uv pip install {{ image.source }}
 {%- if image.upperbounds | default(false) -%}
diff --git a/.github/workflows/build.yml b/.github/workflows/build.yml
index 4923042090..5df5afa88e 100644
--- a/.github/workflows/build.yml
+++ b/.github/workflows/build.yml
@@ -31,16 +31,23 @@ jobs:
       - uses: "actions/setup-python@v6"
         with:
           python-version: "3.11"
+      - name: "Install uv"
+        uses: "astral-sh/setup-uv@v7"
+        with:
+          enable-cache: true
+      - name: "Configure uv to use system Python"
+        run: |
+          echo "UV_SYSTEM_PYTHON=1" >> "$GITHUB_ENV"
       - name: "Install python dependencies"
         run: |
-          pip install build packaging twine wheel mkdocs jq
+          uv pip install build packaging twine wheel mkdocs jq
       - name: "Build package"
         run: |
           python3 -m build
           twine check dist/*
       - name: "Install built packages"
         run: |
-          pip install dist/pulpcore-*-py3-none-any.whl -c .ci/assets/ci_constraints.txt
+          uv pip install dist/pulpcore-*-py3-none-any.whl -c .ci/assets/ci_constraints.txt
       - name: "Generate api specs"
         run: |
           pulpcore-manager openapi --file "api.json"
diff --git a/.github/workflows/ci.yml b/.github/workflows/ci.yml
index 612346b62f..b7e0a38e3d 100644
--- a/.github/workflows/ci.yml
+++ b/.github/workflows/ci.yml
@@ -28,9 +28,16 @@ jobs:
       - uses: "actions/setup-python@v6"
         with:
           python-version: "3.11"
+      - name: "Install uv"
+        uses: "astral-sh/setup-uv@v7"
+        with:
+          enable-cache: true
+      - name: "Configure uv to use system Python"
+        run: |
+          echo "UV_SYSTEM_PYTHON=1" >> "$GITHUB_ENV"
       - name: "Install python dependencies"
         run: |
-          pip install requests pygithub pyyaml
+          uv pip install requests pygithub pyyaml
       - name: "Check commit message"
         if: github.event_name == 'pull_request'
         env:
@@ -56,9 +63,16 @@ jobs:
         with:
           python-version: "3.12"
 
+      - name: "Install uv"
+        uses: "astral-sh/setup-uv@v7"
+        with:
+          enable-cache: true
+      - name: "Configure uv to use system Python"
+        run: |
+          echo "UV_SYSTEM_PYTHON=1" >> "$GITHUB_ENV"
       - name: "Install python dependencies"
         run: |
-          pip install gitpython
+          uv pip install gitpython
 
       - name: "Analyze changed files"
         id: "check"
diff --git a/.github/workflows/create-branch.yml b/.github/workflows/create-branch.yml
index 4456ad95ba..074c3f73e2 100644
--- a/.github/workflows/create-branch.yml
+++ b/.github/workflows/create-branch.yml
@@ -39,9 +39,16 @@ jobs:
         with:
           python-version: "3.11"
 
+      - name: "Install uv"
+        uses: "astral-sh/setup-uv@v7"
+        with:
+          enable-cache: true
+      - name: "Configure uv to use system Python"
+        run: |
+          echo "UV_SYSTEM_PYTHON=1" >> "$GITHUB_ENV"
       - name: "Install python dependencies"
         run: |
-          pip install bump-my-version packaging -r plugin_template/requirements.txt
+          uv pip install bump-my-version packaging -r plugin_template/requirements.txt
 
       - name: "Setting secrets"
         working-directory: "pulpcore"
diff --git a/.github/workflows/docs.yml b/.github/workflows/docs.yml
index 1ccf2f2023..6f925d9d04 100644
--- a/.github/workflows/docs.yml
+++ b/.github/workflows/docs.yml
@@ -29,9 +29,16 @@ jobs:
       - uses: "actions/setup-python@v6"
         with:
           python-version: "3.12"
+      - name: "Install uv"
+        uses: "astral-sh/setup-uv@v7"
+        with:
+          enable-cache: true
+      - name: "Configure uv to use system Python"
+        run: |
+          echo "UV_SYSTEM_PYTHON=1" >> "$GITHUB_ENV"
       - name: "Install python dependencies"
         run: |
-          pip install towncrier
+          uv pip install towncrier
       - name: "Build changelog"
         run: |
           towncrier build --yes --version 4.0.0.ci
diff --git a/.github/workflows/lint.yml b/.github/workflows/lint.yml
index c1a3bbbf86..8571a2f566 100644
--- a/.github/workflows/lint.yml
+++ b/.github/workflows/lint.yml
@@ -28,9 +28,16 @@ jobs:
         with:
           python-version: "3.11"
 
+      - name: "Install uv"
+        uses: "astral-sh/setup-uv@v7"
+        with:
+          enable-cache: true
+      - name: "Configure uv to use system Python"
+        run: |
+          echo "UV_SYSTEM_PYTHON=1" >> "$GITHUB_ENV"
       - name: "Install python dependencies"
         run: |
-          pip install -r lint_requirements.txt
+          uv pip install -r lint_requirements.txt
 
       - name: "Lint workflow files"
         run: |
diff --git a/.github/workflows/nightly.yml b/.github/workflows/nightly.yml
index e7fe433e41..7c827eb5bd 100644
--- a/.github/workflows/nightly.yml
+++ b/.github/workflows/nightly.yml
@@ -45,9 +45,16 @@ jobs:
         with:
           python-version: "3.13"
 
+      - name: "Install uv"
+        uses: "astral-sh/setup-uv@v7"
+        with:
+          enable-cache: true
+      - name: "Configure uv to use system Python"
+        run: |
+          echo "UV_SYSTEM_PYTHON=1" >> "$GITHUB_ENV"
       - name: "Install python dependencies"
         run: |
-          pip install gitpython packaging toml
+          uv pip install gitpython packaging toml
 
       - name: "Configure Git with pulpbot name and email"
         run: |
diff --git a/.github/workflows/pr_checks.yml b/.github/workflows/pr_checks.yml
index 905d0ecc5f..e0e1888dd4 100644
--- a/.github/workflows/pr_checks.yml
+++ b/.github/workflows/pr_checks.yml
@@ -38,9 +38,16 @@ jobs:
       - uses: "actions/setup-python@v6"
         with:
           python-version: "3.11"
+      - name: "Install uv"
+        uses: "astral-sh/setup-uv@v7"
+        with:
+          enable-cache: true
+      - name: "Configure uv to use system Python"
+        run: |
+          echo "UV_SYSTEM_PYTHON=1" >> "$GITHUB_ENV"
       - name: "Determine PR labels"
         run: |
-          pip install GitPython==3.1.42
+          uv pip install GitPython==3.1.42
           git fetch origin ${{ github.event.pull_request.head.sha }}
           python .ci/scripts/pr_labels.py "origin/${{ github.base_ref }}" "${{ github.event.pull_request.head.sha }}" >> "$GITHUB_ENV"
       - uses: "actions/github-script@v8"
diff --git a/.github/workflows/publish.yml b/.github/workflows/publish.yml
index c9535a4966..598dc632aa 100644
--- a/.github/workflows/publish.yml
+++ b/.github/workflows/publish.yml
@@ -131,10 +131,17 @@ jobs:
       - uses: "actions/setup-python@v6"
         with:
           python-version: "3.11"
+      - name: "Install uv"
+        uses: "astral-sh/setup-uv@v7"
+        with:
+          enable-cache: true
+      - name: "Configure uv to use system Python"
+        run: |
+          echo "UV_SYSTEM_PYTHON=1" >> "$GITHUB_ENV"
 
       - name: "Install towncrier"
         run: |
-          pip install towncrier
+          uv pip install towncrier
 
       - name: "Get release notes"
         id: "get_release_notes"
diff --git a/.github/workflows/release.yml b/.github/workflows/release.yml
index 2180377cf0..5a52cb1538 100644
--- a/.github/workflows/release.yml
+++ b/.github/workflows/release.yml
@@ -32,9 +32,16 @@ jobs:
         with:
           python-version: "3.11"
 
+      - name: "Install uv"
+        uses: "astral-sh/setup-uv@v7"
+        with:
+          enable-cache: true
+      - name: "Configure uv to use system Python"
+        run: |
+          echo "UV_SYSTEM_PYTHON=1" >> "$GITHUB_ENV"
       - name: "Install python dependencies"
         run: |
-          pip install bump-my-version towncrier
+          uv pip install bump-my-version towncrier
 
       - name: "Configure Git with pulpbot name and email"
         run: |
diff --git a/.github/workflows/sanity.yml b/.github/workflows/sanity.yml
index 8f4fde3793..ed13802f63 100644
--- a/.github/workflows/sanity.yml
+++ b/.github/workflows/sanity.yml
@@ -31,9 +31,16 @@ jobs:
         with:
           python-version: "3.11"
 
+      - name: "Install uv"
+        uses: "astral-sh/setup-uv@v7"
+        with:
+          enable-cache: true
+      - name: "Configure uv to use system Python"
+        run: |
+          echo "UV_SYSTEM_PYTHON=1" >> "$GITHUB_ENV"
       - name: "Install python dependencies"
         run: |
-          pip install -r lint_requirements.txt
+          uv pip install -r lint_requirements.txt
 
       - name: "Verify bump version config"
         run: |
diff --git a/.github/workflows/scripts/before_script.sh b/.github/workflows/scripts/before_script.sh
index 1c2557eadd..2cad07e509 100755
--- a/.github/workflows/scripts/before_script.sh
+++ b/.github/workflows/scripts/before_script.sh
@@ -39,12 +39,12 @@ echo "# Constraints Files:"
 tail -v -n +1  ../*/*constraints.txt || true
 
 echo
-echo "# pip list outside the container"
-pip list
+echo "# package list outside the container"
+uv pip list
 
 echo
-echo "# pip list inside the container"
-cmd_prefix bash -c "pip3 list"
+echo "# package list inside the container"
+cmd_prefix bash -c "uv pip list"
 
 echo
 echo "# State of the containers"
diff --git a/.github/workflows/scripts/install.sh b/.github/workflows/scripts/install.sh
index 8395faaad6..7ebc2d0d17 100755
--- a/.github/workflows/scripts/install.sh
+++ b/.github/workflows/scripts/install.sh
@@ -17,8 +17,8 @@ source .github/workflows/scripts/utils.sh
 
 PIP_REQUIREMENTS=("pulp-cli" "yq")
 
-# This must be the **only** call to "pip install" on the test runner.
-pip install ${PIP_REQUIREMENTS[*]}
+# This must be the **only** package install on the test runner.
+uv pip install ${PIP_REQUIREMENTS[*]}
 
 if [[ "$TEST" = "s3" ]]; then
 for i in {1..3}
@@ -33,7 +33,7 @@ fi
 fi
 
 # Check out the pulp-cli branch matching the installed version.
-PULP_CLI_VERSION="$(pip freeze | sed -n -e 's/pulp-cli==//p')"
+PULP_CLI_VERSION="$(uv pip freeze | sed -n -e 's/pulp-cli==//p')"
 git clone --depth 1 --branch "$PULP_CLI_VERSION" https://github.com/pulp/pulp-cli.git ../pulp-cli
 
 PULP_API_ROOT="$(yq -r '.pulp_scenario_settings.api_root // .pulp_settings.api_root // "/pulp/"' < .ci/ansible/vars/main.yaml)"
diff --git a/.github/workflows/scripts/script.sh b/.github/workflows/scripts/script.sh
index 65ad9995e0..0ab8f32e65 100755
--- a/.github/workflows/scripts/script.sh
+++ b/.github/workflows/scripts/script.sh
@@ -117,7 +117,7 @@ cmd_stdin_prefix bash -c "cat > /tmp/unittest_requirements.txt" < unittest_requi
 cmd_stdin_prefix bash -c "cat > /tmp/functest_requirements.txt" < functest_requirements.txt
 cmd_stdin_prefix bash -c "cat > /tmp/bindings_requirements.txt" < bindings_requirements.txt
 cmd_stdin_prefix bash -c "cat > /tmp/bindings_constraints.txt" < bindings_constraints.txt
-cmd_prefix pip3 install -r /tmp/unittest_requirements.txt -r /tmp/functest_requirements.txt -r /tmp/bindings_requirements.txt -c /tmp/bindings_constraints.txt
+cmd_prefix uv pip install -r /tmp/unittest_requirements.txt -r /tmp/functest_requirements.txt -r /tmp/bindings_requirements.txt -c /tmp/bindings_constraints.txt
 
 CERTIFI=$(cmd_prefix python3 -c 'import certifi; print(certifi.where())')
 cmd_prefix bash -c "cat /etc/pulp/certs/pulp_webserver.crt >> '$CERTIFI'"
@@ -170,12 +170,15 @@ export PULP_FIXTURES_URL="http://pulp-fixtures:8080"
 # some pulp-cli tests use the api root envvar
 export PULP_API_ROOT="$(EDITOR=cat pulp config edit 2>/dev/null | awk -F'"' '/api_root/{print $2; exit}')"
 pushd ../pulp-cli
+# livetests are parallel-safe (pytest-xdist).
+CLI_MARK="live and (pulpcore or pulp_file or pulp_certguard)"
 if [[ -f "test_requirements.txt" ]]
 then
-  pip install -r test_requirements.txt
-  pytest -v tests -m "pulpcore or pulp_file or pulp_certguard"
+  uv pip install -r test_requirements.txt
+  pytest -v tests -m "${CLI_MARK}" -n 8
 else
-  PULP_CA_BUNDLE="/usr/local/share/ca-certificates/pulp_webserver.crt" make livetest PYTEST_MARK="live and (pulpcore or pulp_file or pulp_certguard)"
+  PULP_CA_BUNDLE="/usr/local/share/ca-certificates/pulp_webserver.crt" \
+    uv run pytest -v tests pulp-glue/tests -m "${CLI_MARK}" -n 8
 fi
 popd
 
diff --git a/.github/workflows/test.yml b/.github/workflows/test.yml
index 833c98e4f8..f5ab84dde0 100644
--- a/.github/workflows/test.yml
+++ b/.github/workflows/test.yml
@@ -42,11 +42,6 @@ jobs:
         with:
           python-version: "3.11"
 
-      - name: "Install uv"
-        uses: "astral-sh/setup-uv@v7"
-        with:
-          enable-cache: true
-
       - name: "Download plugin package"
         uses: "actions/download-artifact@v8"
         with:
@@ -81,9 +76,16 @@ jobs:
           tar xvf "../../pulpcore/certguard-python-client.tar"
           popd
 
+      - name: "Install uv"
+        uses: "astral-sh/setup-uv@v7"
+        with:
+          enable-cache: true
+      - name: "Configure uv to use system Python"
+        run: |
+          echo "UV_SYSTEM_PYTHON=1" >> "$GITHUB_ENV"
       - name: "Install python dependencies"
         run: |
-          pip install build towncrier twine wheel httpie docker netaddr boto3 'ansible~=10.3.0' mkdocs jq jsonpatch bump-my-version
+          uv pip install build towncrier twine wheel httpie docker netaddr boto3 'ansible~=10.3.0' mkdocs jq jsonpatch bump-my-version
           echo "HTTPIE_CONFIG_DIR=$GITHUB_WORKSPACE/pulpcore/.ci/assets/httpie/" >> $GITHUB_ENV
 
       - name: "Set environment variables"
@@ -153,5 +155,5 @@ jobs:
           docker logs pulp || true
           docker exec pulp ls -latr /etc/yum.repos.d/ || true
           docker exec pulp cat /etc/yum.repos.d/* || true
-          docker exec pulp bash -c "pip3 list" || true
+          docker exec pulp bash -c "uv pip list" || true
 ...
diff --git a/.github/workflows/update-labels.yml b/.github/workflows/update-labels.yml
index 6ae6a0245a..dc6c127a9c 100644
--- a/.github/workflows/update-labels.yml
+++ b/.github/workflows/update-labels.yml
@@ -26,9 +26,16 @@ jobs:
         run: |
           git config --global user.name 'pulpbot'
           git config --global user.email 'pulp-infra@redhat.com'
+      - name: "Install uv"
+        uses: "astral-sh/setup-uv@v7"
+        with:
+          enable-cache: true
+      - name: "Configure uv to use system Python"
+        run: |
+          echo "UV_SYSTEM_PYTHON=1" >> "$GITHUB_ENV"
       - name: "Install python dependencies"
         run: |
-          pip install requests pyyaml
+          uv pip install requests pyyaml
       - uses: "actions/checkout@v6"
       - name: "Update labels"
         run: |
diff --git a/.github/workflows/update_ci.yml b/.github/workflows/update_ci.yml
index 3971659514..2816f1b9ef 100644
--- a/.github/workflows/update_ci.yml
+++ b/.github/workflows/update_ci.yml
@@ -33,9 +33,16 @@ jobs:
         with:
           python-version: "3.11"
 
+      - name: "Install uv"
+        uses: "astral-sh/setup-uv@v7"
+        with:
+          enable-cache: true
+      - name: "Configure uv to use system Python"
+        run: |
+          echo "UV_SYSTEM_PYTHON=1" >> "$GITHUB_ENV"
       - name: "Install python dependencies"
         run: |
-          pip install gitpython packaging -r plugin_template/requirements.txt
+          uv pip install gitpython packaging -r plugin_template/requirements.txt
 
       - name: "Configure Git with pulpbot name and email"
         run: |
diff --git a/CHANGES/+ci-parallel-cli-uv.misc b/CHANGES/+ci-parallel-cli-uv.misc
new file mode 100644
index 0000000000..047d275671
--- /dev/null
+++ b/CHANGES/+ci-parallel-cli-uv.misc
@@ -0,0 +1 @@
+Run pulp-cli livetests in parallel with pytest-xdist, and use uv instead of pip in CI.