diff --git a/score-server/README.md b/score-server/README.md
index 873f4e87..9b3e710d 100644
--- a/score-server/README.md
+++ b/score-server/README.md
@@ -44,7 +44,28 @@ bucket:
 download:
   partsize: 250000000  # 250 MB
 ```
-At this time, only a single Azure Blob Storage account (and container) is used. However, since Azure Storage can only store 500 TB per account, the Storage Server will need to manage multiple account/key credentials in the near future.  It may also make sense to have multiple containers per account as well. There are suggestions that having many objects in a single container can impose a performance penalty on some operations.
+### S3 Configuration
+To configure SCORe to use an S3-compatible object storage service, the s3 Spring profile must be activated. This profile is designed to work with services like AWS S3, MinIO, or any other compatible service. Below are the configuration properties available under the s3 section in application.yml, along with their descriptions:
+
+Profile Name: ``s3``
+
+# Configuration Properties
+
+| Property | Description |
+| ------------- | ------------- |
+|`s3.secured`  | Determines whether the connection to the S3 service should use HTTPS (true) or HTTP (false). Set to true to secure the connection. |
+|`s3.endpoint` |The URL of the S3-compatible service. This is the endpoint where the service is hosted. This property should be provided based on the service you're using.
+|`s3.accessKey` |The access key for authenticating with the S3 service. It's required for secure access and should be kept confidential.|
+|`s3.secretKey`|The secret key paired with the access key for secure authentication to the S3 service. It must also be kept confidential.|
+|`s3.masterEncryptionKeyId`|The ID of the encryption key used for server-side encryption of files stored in S3. If provided, this key ensures that all data at rest is encrypted using the specified key.|
+|`s3.customMd5Property`| A custom metadata property that stores an MD5 checksum of the uploaded files. This is useful for validating the integrity of the files.|
+|`s3.connectionTimeout`| The maximum amount of time (in milliseconds) the client will wait to establish a connection to the S3 service before timing out. This helps manage delays in the network or service availability.|
+|`s3.retryLimit`| The number of retries the client will attempt if an operation fails (e.g., an upload). This helps ensure robustness in case of transient issues.
+|`s3.sigV4Enabled`| Enables AWS Signature Version 4 for request signing. This is required for certain regions or when using advanced features like server-side encryption with AWS KMS.|
+
+
+> [!NOTE]  
+> At this time, only a single Azure Blob Storage account (and container) is used. However, since Azure Storage can only store 500 TB per account, the Storage Server will need to manage multiple account/key credentials in the near future.  It may also make sense to have multiple containers per account as well. There are suggestions that having many objects in a single container can impose a performance penalty on some operations.
 
 The Storage Server no longer uses ``.meta`` files to track state in the repository. Object Specifications are dynamically generated on the fly for use on the client (to allow downloads to be resumed). Also, the block upload implementation supplied by Microsoft in the Azure Java SDK supercedes the use of this file. 
 
diff --git a/score-server/src/main/java/bio/overture/score/server/config/S3Config.java b/score-server/src/main/java/bio/overture/score/server/config/S3Config.java
index 927e19ab..310b8b8c 100644
--- a/score-server/src/main/java/bio/overture/score/server/config/S3Config.java
+++ b/score-server/src/main/java/bio/overture/score/server/config/S3Config.java
@@ -19,13 +19,11 @@
 import org.springframework.boot.context.properties.ConfigurationProperties;
 import org.springframework.context.annotation.Bean;
 import org.springframework.context.annotation.Configuration;
-import org.springframework.context.annotation.Profile;
 
 /** S3/Ceph Object Gateway configuration. */
 @Data
 @Slf4j
 @Configuration
-@Profile({"aws", "collaboratory", "default"})
 @ConfigurationProperties(prefix = "s3")
 public class S3Config {
 
diff --git a/score-server/src/main/java/bio/overture/score/server/config/ServerConfig.java b/score-server/src/main/java/bio/overture/score/server/config/ServerConfig.java
index 4e8f6d6c..29bcc411 100644
--- a/score-server/src/main/java/bio/overture/score/server/config/ServerConfig.java
+++ b/score-server/src/main/java/bio/overture/score/server/config/ServerConfig.java
@@ -29,11 +29,9 @@
 import org.springframework.beans.factory.annotation.Value;
 import org.springframework.context.annotation.Bean;
 import org.springframework.context.annotation.Configuration;
-import org.springframework.context.annotation.Profile;
 
 /** Server level configuration */
 @Configuration
-@Profile({"aws", "collaboratory", "default"})
 public class ServerConfig {
 
   @Value("${upload.partsize}")
diff --git a/score-server/src/main/java/bio/overture/score/server/health/BackendHealth.java b/score-server/src/main/java/bio/overture/score/server/health/BackendHealth.java
index 22b26a81..b92268fa 100644
--- a/score-server/src/main/java/bio/overture/score/server/health/BackendHealth.java
+++ b/score-server/src/main/java/bio/overture/score/server/health/BackendHealth.java
@@ -22,12 +22,10 @@
 import org.springframework.beans.factory.annotation.Value;
 import org.springframework.boot.actuate.health.Health;
 import org.springframework.boot.actuate.health.HealthIndicator;
-import org.springframework.context.annotation.Profile;
 import org.springframework.stereotype.Component;
 
 /** check health for object upload service */
 @Component
-@Profile({"aws", "collaboratory", "default"})
 public class BackendHealth implements HealthIndicator {
 
   @Autowired AmazonS3 s3;
diff --git a/score-server/src/main/java/bio/overture/score/server/repository/s3/S3DownloadService.java b/score-server/src/main/java/bio/overture/score/server/repository/s3/S3DownloadService.java
index bf8ceb7e..2909c005 100644
--- a/score-server/src/main/java/bio/overture/score/server/repository/s3/S3DownloadService.java
+++ b/score-server/src/main/java/bio/overture/score/server/repository/s3/S3DownloadService.java
@@ -55,7 +55,6 @@
 import lombok.val;
 import org.springframework.beans.factory.annotation.Autowired;
 import org.springframework.beans.factory.annotation.Value;
-import org.springframework.context.annotation.Profile;
 import org.springframework.http.HttpStatus;
 import org.springframework.stereotype.Service;
 
@@ -63,7 +62,6 @@
 @Slf4j
 @Setter
 @Service
-@Profile({"aws", "collaboratory", "default"})
 public class S3DownloadService implements DownloadService {
 
   /** Constants. */
diff --git a/score-server/src/main/java/bio/overture/score/server/repository/s3/S3ListingService.java b/score-server/src/main/java/bio/overture/score/server/repository/s3/S3ListingService.java
index 8e357056..22caf5f3 100644
--- a/score-server/src/main/java/bio/overture/score/server/repository/s3/S3ListingService.java
+++ b/score-server/src/main/java/bio/overture/score/server/repository/s3/S3ListingService.java
@@ -36,14 +36,12 @@
 import org.springframework.beans.factory.annotation.Autowired;
 import org.springframework.beans.factory.annotation.Value;
 import org.springframework.cache.annotation.Cacheable;
-import org.springframework.context.annotation.Profile;
 import org.springframework.http.HttpStatus;
 import org.springframework.stereotype.Service;
 
 @Slf4j
 @Setter
 @Service
-@Profile({"aws", "collaboratory", "default"})
 public class S3ListingService implements ListingService {
 
   /** Configuration. */
@@ -109,8 +107,10 @@ private List<ObjectInfo> listBucketContents(String bucket) {
   }
 
   private void readBucket(String bucketName, String prefix, Consumer<S3ObjectSummary> callback) {
-    val request = prefix.isBlank() ? new ListObjectsRequest().withBucketName(bucketName) :
-            new ListObjectsRequest().withBucketName(bucketName).withPrefix(prefix);
+    val request =
+        prefix.isBlank()
+            ? new ListObjectsRequest().withBucketName(bucketName)
+            : new ListObjectsRequest().withBucketName(bucketName).withPrefix(prefix);
     log.debug("Reading summaries from '{}/{}'...", bucketName, prefix);
 
     ObjectListing listing;
diff --git a/score-server/src/main/java/bio/overture/score/server/repository/s3/S3UploadService.java b/score-server/src/main/java/bio/overture/score/server/repository/s3/S3UploadService.java
index 85178fa1..8abaedb8 100644
--- a/score-server/src/main/java/bio/overture/score/server/repository/s3/S3UploadService.java
+++ b/score-server/src/main/java/bio/overture/score/server/repository/s3/S3UploadService.java
@@ -46,7 +46,6 @@
 import lombok.val;
 import org.springframework.beans.factory.annotation.Autowired;
 import org.springframework.beans.factory.annotation.Value;
-import org.springframework.context.annotation.Profile;
 import org.springframework.http.HttpStatus;
 import org.springframework.stereotype.Service;
 import org.springframework.web.client.RestClientException;
@@ -55,7 +54,6 @@
 @Slf4j
 @Setter
 @Service
-@Profile({"aws", "collaboratory", "default"})
 public class S3UploadService implements UploadService {
 
   /** Constants. */
diff --git a/score-server/src/main/resources/application.yml b/score-server/src/main/resources/application.yml
index 47587ca1..9ac6d731 100644
--- a/score-server/src/main/resources/application.yml
+++ b/score-server/src/main/resources/application.yml
@@ -130,68 +130,64 @@ server:
 ---
 
 ###############################################################################
-# Profile - "amazon"
+# Profile - "azure"
 ###############################################################################
 
 spring:
   config:
     activate:
-      on-profile: amazon
+      on-profile: azure
 
-s3:
-  endpoint: s3-external-1.amazonaws.com
-  masterEncryptionKeyId: af628f04-ac12-4b11-bf83-6545fd44ad18
+azure:
+  endpointProtocol: https
+  accountName: oicricgc
+  accountKey:
 
 bucket:
-  name.object: oicr.icgc
-  name.state: oicr.icgc
+  name.object: data
+  policy.upload: UploadPolicy
+  policy.download: DownloadPolicy
 
-metadata:
-  url: https://virginia.song.icgc.org
-  useLegacyMode: false
+download:
+  partsize: 250000000
 
 ---
-
 ###############################################################################
-# Profile - "collaboratory"
+# Profile - "s3"
 ###############################################################################
 
 spring:
   config:
     activate:
-      on-profile: collaboratory
+      on-profile: s3
 
 s3:
-  endpoint: https://object.cancercollaboratory.org:9080
-  masterEncryptionKeyId:
+  # Whether the connection should use HTTPS (true) or HTTP (false)
+  secured: true
 
-metadata:
-  url: https://song.cancercollaboratory.org
-  useLegacyMode: false
+  # Endpoint URL for the S3-compatible service
+  # endpoint: your-s3-endpoint
 
----
+  # Access key for authentication
+  # accessKey: your-access-key
 
-###############################################################################
-# Profile - "azure"
-###############################################################################
+  # Secret key for authentication
+  # secretKey: your-secret-key
 
-spring:
-  config:
-    activate:
-      on-profile: azure
+  # Master encryption key ID for server-side encryption
+  # masterEncryptionKeyId: your-encryption-key-id
 
-azure:
-  endpointProtocol: https
-  accountName: oicricgc
-  accountKey:
+  # Custom MD5 checksum property (if needed)
+  customMd5Property: md5chksum
 
-bucket:
-  name.object: data
-  policy.upload: UploadPolicy
-  policy.download: DownloadPolicy
+  # Connection timeout in milliseconds
+  connectionTimeout: 15000
 
-download:
-  partsize: 250000000
+  # Retry limit for failed operations
+  retryLimit: 5
+
+  # Whether to use Signature Version 4
+  sigV4Enabled: true
 
 ---