diff --git a/eng/Version.Details.xml b/eng/Version.Details.xml
index b33c97d739a470..c5387f43840741 100644
--- a/eng/Version.Details.xml
+++ b/eng/Version.Details.xml
@@ -38,7 +38,7 @@
       <Uri>https://github.com/dotnet/arcade</Uri>
       <Sha>1d951297eb7bdd29a31dff3149606152717ed6b4</Sha>
     </Dependency>
-    <Dependency Name="Microsoft.DotNet.Build.Tasks.Packaging" Version="6.0.0-beta.21219.2">
+    <Dependency Name="Microsoft.DotNet.Build.Tasks.Packaging" Version="6.0.0-beta.21221.6">
       <Uri>https://github.com/dotnet/arcade</Uri>
       <Sha>1d951297eb7bdd29a31dff3149606152717ed6b4</Sha>
     </Dependency>
diff --git a/eng/Versions.props b/eng/Versions.props
index c8145363caba1d..4843d85ea9200b 100644
--- a/eng/Versions.props
+++ b/eng/Versions.props
@@ -62,7 +62,7 @@
     <MicrosoftDotNetXUnitExtensionsVersion>6.0.0-beta.21219.2</MicrosoftDotNetXUnitExtensionsVersion>
     <MicrosoftDotNetXUnitConsoleRunnerVersion>2.5.1-beta.21219.2</MicrosoftDotNetXUnitConsoleRunnerVersion>
     <MicrosoftDotNetBuildTasksArchivesVersion>6.0.0-beta.21219.2</MicrosoftDotNetBuildTasksArchivesVersion>
-    <MicrosoftDotNetBuildTasksPackagingVersion>6.0.0-beta.21219.2</MicrosoftDotNetBuildTasksPackagingVersion>
+    <MicrosoftDotNetBuildTasksPackagingVersion>6.0.0-beta.21221.6</MicrosoftDotNetBuildTasksPackagingVersion>
     <MicrosoftDotNetBuildTasksInstallersVersion>6.0.0-beta.21219.2</MicrosoftDotNetBuildTasksInstallersVersion>
     <MicrosoftDotNetRemoteExecutorVersion>6.0.0-beta.21219.2</MicrosoftDotNetRemoteExecutorVersion>
     <MicrosoftDotNetVersionToolsTasksVersion>6.0.0-beta.21219.2</MicrosoftDotNetVersionToolsTasksVersion>
diff --git a/src/libraries/Microsoft.Extensions.DependencyModel/pkg/Microsoft.Extensions.DependencyModel.pkgproj b/src/libraries/Microsoft.Extensions.DependencyModel/pkg/Microsoft.Extensions.DependencyModel.pkgproj
index 6d9d2b9a687977..ba0c44534e47a2 100644
--- a/src/libraries/Microsoft.Extensions.DependencyModel/pkg/Microsoft.Extensions.DependencyModel.pkgproj
+++ b/src/libraries/Microsoft.Extensions.DependencyModel/pkg/Microsoft.Extensions.DependencyModel.pkgproj
@@ -4,8 +4,8 @@
     <ProjectReference Include="..\src\Microsoft.Extensions.DependencyModel.csproj">
       <SupportedFramework>net461;netcoreapp2.0;uap10.0.16299;$(AllXamarinFrameworks)</SupportedFramework>
     </ProjectReference>
-    <!-- Elements from previous packages that will be included in the newly built package -->
-    <HarvestIncludePaths Include="lib/net451;lib/netstandard1.3;lib/netstandard1.6" />
+    <!-- Exclude TFMs that aren't supported by the package anymore from validation. -->
+    <ExcludeHarvestedSupportedFramework Include="netcoreapp1.0;netcoreapp1.1;netcore50;uap10.0;net451;net46" />
   </ItemGroup>
   <Import Project="$([MSBuild]::GetPathOfFileAbove(Directory.Build.targets))" />
 </Project>
diff --git a/src/libraries/Microsoft.Extensions.DependencyModel/src/Microsoft.Extensions.DependencyModel.csproj b/src/libraries/Microsoft.Extensions.DependencyModel/src/Microsoft.Extensions.DependencyModel.csproj
index ce27427b2ca9ce..500f16e87b06c1 100644
--- a/src/libraries/Microsoft.Extensions.DependencyModel/src/Microsoft.Extensions.DependencyModel.csproj
+++ b/src/libraries/Microsoft.Extensions.DependencyModel/src/Microsoft.Extensions.DependencyModel.csproj
@@ -3,10 +3,6 @@
     <TargetFrameworks>netstandard2.0;net461</TargetFrameworks>
     <EnableDefaultItems>true</EnableDefaultItems>
   </PropertyGroup>
-  <PropertyGroup>
-    <!-- Ensure Assemblies are first resolved via targeting pack when targeting net461 -->
-    <AssemblySearchPaths Condition="'$(TargetFramework)' == 'net461'">$(NuGetPackageRoot)\microsoft.targetingpack.netframework.v4.6.1\1.0.1\lib\net461\;$(AssemblySearchPaths)</AssemblySearchPaths>
-  </PropertyGroup>
 
   <ItemGroup>
     <Compile Include="$(CoreLibSharedDir)\System\Numerics\Hashing\HashHelpers.cs"
@@ -17,9 +13,9 @@
     <InternalsVisibleTo Include="Microsoft.Extensions.DependencyModel.Tests" /> 
   </ItemGroup>
 
-  <ItemGroup Condition="$(TargetFramework.StartsWith('net4'))">
+  <ItemGroup Condition="'$(TargetFramework)' == 'net461'">
     <Reference Include="System.Runtime" />
-    <PackageReference Include="System.Runtime.InteropServices.RuntimeInformation" Version="4.3.0" Condition="'$(TargetFramework)' == 'net461'" />
+    <PackageReference Include="System.Runtime.InteropServices.RuntimeInformation" Version="4.3.0" />
   </ItemGroup>
 
   <ItemGroup>
@@ -29,5 +25,4 @@
     <ProjectReference Include="$(LibrariesProjectRoot)System.Text.Encodings.Web\src\System.Text.Encodings.Web.csproj" />
     <ProjectReference Include="$(LibrariesProjectRoot)System.Text.Json\src\System.Text.Json.csproj" />
   </ItemGroup>
-
 </Project>