diff --git a/src/libraries/Directory.Build.targets b/src/libraries/Directory.Build.targets
index 0df45c84d2847b..16edbbd3475623 100644
--- a/src/libraries/Directory.Build.targets
+++ b/src/libraries/Directory.Build.targets
@@ -235,7 +235,7 @@
   </Choose>
 
   <PropertyGroup>
-    <ExcludeFromPackage Condition="'$(TargetFramework)' == '$(NetCoreAppCurrent)' and '$(ExcludeCurrentNetCoreAppFromPackage)' == 'true'">true</ExcludeFromPackage>
+    <ExcludeFromPackage Condition="$([MSBuild]::IsTargetFrameworkCompatible('$(TargetFramework)', '$(NetCoreAppCurrent)')) and '$(ExcludeCurrentNetCoreAppFromPackage)' == 'true'">true</ExcludeFromPackage>
   </PropertyGroup>
 
   <!-- Adds System.Runtime.Versioning*Platform* annotation attributes to < .NET 5 builds -->
@@ -268,7 +268,7 @@
   </ItemGroup>
 
   <PropertyGroup>
-    <SkipLocalsInit Condition="'$(SkipLocalsInit)' == '' and '$(MSBuildProjectExtension)' == '.csproj' and '$(IsNETCoreAppSrc)' == 'true' and '$(TargetFramework)' == '$(NetCoreAppCurrent)'">true</SkipLocalsInit>
+    <SkipLocalsInit Condition="'$(SkipLocalsInit)' == '' and '$(MSBuildProjectExtension)' == '.csproj' and '$(IsNETCoreAppSrc)' == 'true' and ($([MSBuild]::IsTargetFrameworkCompatible('$(TargetFramework)', '$(NetCoreAppCurrent)')))">true</SkipLocalsInit>
   </PropertyGroup>
 
   <!--Instructs compiler not to emit .locals init, using SkipLocalsInitAttribute.-->
diff --git a/src/libraries/Microsoft.Win32.Registry/src/Microsoft.Win32.Registry.csproj b/src/libraries/Microsoft.Win32.Registry/src/Microsoft.Win32.Registry.csproj
index c372d739a90a7b..ab962d316335ae 100644
--- a/src/libraries/Microsoft.Win32.Registry/src/Microsoft.Win32.Registry.csproj
+++ b/src/libraries/Microsoft.Win32.Registry/src/Microsoft.Win32.Registry.csproj
@@ -77,7 +77,7 @@
     <ProjectReference Include="$(LibrariesProjectRoot)System.Security.AccessControl\src\System.Security.AccessControl.csproj" />
     <ProjectReference Include="$(LibrariesProjectRoot)System.Security.Principal.Windows\src\System.Security.Principal.Windows.csproj" />
   </ItemGroup>
-  <ItemGroup Condition="'$(TargetFramework)' == '$(NetCoreAppCurrent)'">
+  <ItemGroup Condition="$([MSBuild]::IsTargetFrameworkCompatible('$(TargetFramework)', '$(NetCoreAppCurrent)'))">
     <Reference Include="System.Buffers" />
     <Reference Include="System.Collections" />
     <Reference Include="System.Diagnostics.Debug" />
diff --git a/src/libraries/Microsoft.Win32.SystemEvents/src/Microsoft.Win32.SystemEvents.csproj b/src/libraries/Microsoft.Win32.SystemEvents/src/Microsoft.Win32.SystemEvents.csproj
index 4cdba1a506ea85..b3e8685624b081 100644
--- a/src/libraries/Microsoft.Win32.SystemEvents/src/Microsoft.Win32.SystemEvents.csproj
+++ b/src/libraries/Microsoft.Win32.SystemEvents/src/Microsoft.Win32.SystemEvents.csproj
@@ -113,7 +113,7 @@
     <Compile Include="Microsoft\Win32\UserPreferenceChangingEventArgs.cs" />
     <Compile Include="Microsoft\Win32\UserPreferenceChangingEventHandler.cs" />
   </ItemGroup>
-  <ItemGroup Condition="'$(TargetFramework)' != '$(NetCoreAppCurrent)'">
+  <ItemGroup Condition="!$([MSBuild]::IsTargetFrameworkCompatible('$(TargetFramework)', '$(NetCoreAppCurrent)'))">
     <Compile Include="$(CoreLibSharedDir)System\Runtime\InteropServices\SuppressGCTransitionAttribute.cs"
              Link="System\Runtime\InteropServices\SuppressGCTransitionAttribute.cs" />
   </ItemGroup>
diff --git a/src/libraries/System.Data.Odbc/src/System.Data.Odbc.csproj b/src/libraries/System.Data.Odbc/src/System.Data.Odbc.csproj
index e118672a4a0a82..9286d2cfebd220 100644
--- a/src/libraries/System.Data.Odbc/src/System.Data.Odbc.csproj
+++ b/src/libraries/System.Data.Odbc/src/System.Data.Odbc.csproj
@@ -10,7 +10,7 @@
   <PropertyGroup>
     <IsPartialFacadeAssembly Condition="$(TargetFramework.StartsWith('net4'))">true</IsPartialFacadeAssembly>
     <!-- https://github.com/dotnet/arcade/issues/5717 -->
-    <NoWarn Condition="'$(TargetFramework)' == '$(NetCoreAppCurrent)' and '$(TargetsAnyOS)' == 'true'">$(NoWarn);SA1121</NoWarn>
+    <NoWarn Condition="($([MSBuild]::IsTargetFrameworkCompatible('$(TargetFramework)', '$(NetCoreAppCurrent)'))) and '$(TargetsAnyOS)' == 'true'">$(NoWarn);SA1121</NoWarn>
     <GeneratePlatformNotSupportedAssemblyMessage Condition="'$(TargetFramework)' == 'netstandard2.0' or '$(TargetsAnyOS)' == 'true'">SR.Odbc_PlatformNotSupported</GeneratePlatformNotSupportedAssemblyMessage>
   </PropertyGroup>
   <ItemGroup Condition="$(TargetFramework.StartsWith('$(NetCoreAppCurrent)')) or $(TargetFramework.StartsWith('netcoreapp2.0'))" >
diff --git a/src/libraries/System.Diagnostics.Process/src/System.Diagnostics.Process.csproj b/src/libraries/System.Diagnostics.Process/src/System.Diagnostics.Process.csproj
index e9f2630e6f0cc2..750902104e1c06 100644
--- a/src/libraries/System.Diagnostics.Process/src/System.Diagnostics.Process.csproj
+++ b/src/libraries/System.Diagnostics.Process/src/System.Diagnostics.Process.csproj
@@ -295,7 +295,7 @@
     <Compile Include="$(CommonPath)Interop\OSX\Interop.Libraries.cs"
              Link="Common\Interop\OSX\Interop.Libraries.cs" />
   </ItemGroup>
-  <ItemGroup Condition="'$(TargetFramework)' == '$(NetCoreAppCurrent)' and '$(TargetsWindows)' == 'true'">
+  <ItemGroup Condition="$([MSBuild]::IsTargetFrameworkCompatible('$(TargetFramework)', '$(NetCoreAppCurrent)')) and '$(TargetsWindows)' == 'true'">
     <Compile Include="$(CommonPath)Interop\Windows\Shell32\Interop.ShellExecuteExW.cs"
              Link="Common\Interop\Windows\Shell32\Interop.ShellExecuteExW.cs" />
     <Compile Include="System\Diagnostics\Process.Win32.cs" />
diff --git a/src/libraries/System.IO.FileSystem.DriveInfo/src/System.IO.FileSystem.DriveInfo.csproj b/src/libraries/System.IO.FileSystem.DriveInfo/src/System.IO.FileSystem.DriveInfo.csproj
index fdc1f7b5f018a9..cac7326d0c2cf9 100644
--- a/src/libraries/System.IO.FileSystem.DriveInfo/src/System.IO.FileSystem.DriveInfo.csproj
+++ b/src/libraries/System.IO.FileSystem.DriveInfo/src/System.IO.FileSystem.DriveInfo.csproj
@@ -49,7 +49,7 @@
     <Compile Include="$(CommonPath)System\IO\PathInternal.Windows.cs"
              Link="Common\System\IO\PathInternal.Windows.cs" />
   </ItemGroup>
-  <ItemGroup Condition="'$(TargetsUnix)' == 'true' And '$(TargetFramework)' == '$(NetCoreAppCurrent)' ">
+  <ItemGroup Condition="'$(TargetsUnix)' == 'true' And $([MSBuild]::IsTargetFrameworkCompatible('$(TargetFramework)', '$(NetCoreAppCurrent)'))">
     <Compile Include="System\IO\DriveInfo.UnixOrBrowser.cs" />
     <Compile Include="System\IO\DriveInfo.Unix.cs" />
     <Compile Include="$(CommonPath)Interop\Unix\Interop.Libraries.cs"
@@ -67,7 +67,7 @@
     <Compile Include="$(CommonPath)Interop\Unix\System.Native\Interop.MountPoints.FormatInfo.cs"
              Link="Common\Interop\Unix\Interop.MountPoints.FormatInfo.cs" />
   </ItemGroup>
-  <ItemGroup Condition="'$(TargetsBrowser)' == 'true' And '$(TargetFramework)' == '$(NetCoreAppCurrent)' ">
+  <ItemGroup Condition="'$(TargetsBrowser)' == 'true' And ($([MSBuild]::IsTargetFrameworkCompatible('$(TargetFramework)', '$(NetCoreAppCurrent)'))) ">
     <Compile Include="System\IO\DriveInfo.UnixOrBrowser.cs" />
     <Compile Include="System\IO\DriveInfo.Browser.cs" />
   </ItemGroup>
diff --git a/src/libraries/System.Net.Http/tests/UnitTests/System.Net.Http.Unit.Tests.csproj b/src/libraries/System.Net.Http/tests/UnitTests/System.Net.Http.Unit.Tests.csproj
index c4dfd640d9a46e..72fb0d8fb49eb1 100644
--- a/src/libraries/System.Net.Http/tests/UnitTests/System.Net.Http.Unit.Tests.csproj
+++ b/src/libraries/System.Net.Http/tests/UnitTests/System.Net.Http.Unit.Tests.csproj
@@ -240,17 +240,17 @@
              Link="ProductionCode\System\Net\Http\StringContent.cs" />
     <Compile Include="..\..\src\System\Net\Http\SocketsHttpHandler\HttpEnvironmentProxy.cs"
              Link="ProductionCode\System\Net\Http\SocketsHttpHandler\HttpEnvironmentProxy.cs" />
-    <Compile Include="..\..\src\System\Net\Http\SocketsHttpHandler\HttpEnvironmentProxy.Unix.cs" Condition="('$(TargetsUnix)' == 'true' or '$(TargetsBrowser)' == 'true') and '$(TargetFramework)' == '$(NetCoreAppCurrent)'"
+    <Compile Include="..\..\src\System\Net\Http\SocketsHttpHandler\HttpEnvironmentProxy.Unix.cs" Condition="('$(TargetsUnix)' == 'true' or '$(TargetsBrowser)' == 'true') and $([MSBuild]::IsTargetFrameworkCompatible('$(TargetFramework)', '$(NetCoreAppCurrent)'))"
              Link="ProductionCode\System\Net\Http\SocketsHttpHandler\HttpEnvironmentProxy.Unix.cs" />
-    <Compile Include="..\..\src\System\Net\Http\SocketsHttpHandler\HttpEnvironmentProxy.Windows.cs" Condition=" '$(TargetsWindows)' == 'true' and '$(TargetFramework)' == '$(NetCoreAppCurrent)'"
+    <Compile Include="..\..\src\System\Net\Http\SocketsHttpHandler\HttpEnvironmentProxy.Windows.cs" Condition=" '$(TargetsWindows)' == 'true' and $([MSBuild]::IsTargetFrameworkCompatible('$(TargetFramework)', '$(NetCoreAppCurrent)'))"
              Link="ProductionCode\System\Net\Http\SocketsHttpHandler\HttpEnvironmentProxy.Windows.cs" />
     <Compile Include="..\..\src\System\Net\Http\SocketsHttpHandler\SystemProxyInfo.cs"
              Link="ProductionCode\System\Net\Http\SocketsHttpHandler\SystemProxyInfo.cs" />
-    <Compile Include="..\..\src\System\Net\Http\SocketsHttpHandler\SystemProxyInfo.OSX.cs" Condition=" ('$(TargetsOSX)' == 'true' or '$(TargetsiOS)' == 'true' or '$(TargetstvOS)' == 'true') and '$(TargetFramework)' == '$(NetCoreAppCurrent)'"
+    <Compile Include="..\..\src\System\Net\Http\SocketsHttpHandler\SystemProxyInfo.OSX.cs" Condition=" ('$(TargetsOSX)' == 'true' or '$(TargetsiOS)' == 'true' or '$(TargetstvOS)' == 'true') and $([MSBuild]::IsTargetFrameworkCompatible('$(TargetFramework)', '$(NetCoreAppCurrent)'))"
              Link="ProductionCode\System\Net\Http\SocketsHttpHandler\SystemProxyInfo.OSX.cs" />
-    <Compile Include="..\..\src\System\Net\Http\SocketsHttpHandler\SystemProxyInfo.Unix.cs" Condition="('$(TargetsUnix)' == 'true' or '$(TargetsBrowser)' == 'true') and '$(TargetsOSX)' != 'true' and '$(TargetsiOS)' != 'true' and '$(TargetstvOS)' != 'true' and '$(TargetFramework)' == '$(NetCoreAppCurrent)'"
+    <Compile Include="..\..\src\System\Net\Http\SocketsHttpHandler\SystemProxyInfo.Unix.cs" Condition="('$(TargetsUnix)' == 'true' or '$(TargetsBrowser)' == 'true') and '$(TargetsOSX)' != 'true' and '$(TargetsiOS)' != 'true' and '$(TargetstvOS)' != 'true' and $([MSBuild]::IsTargetFrameworkCompatible('$(TargetFramework)', '$(NetCoreAppCurrent)'))"
              Link="ProductionCode\System\Net\Http\SocketsHttpHandler\SystemProxyInfo.Unix.cs" />
-    <Compile Include="..\..\src\System\Net\Http\SocketsHttpHandler\SystemProxyInfo.Windows.cs" Condition=" '$(TargetsWindows)' == 'true' and '$(TargetFramework)' == '$(NetCoreAppCurrent)'"
+    <Compile Include="..\..\src\System\Net\Http\SocketsHttpHandler\SystemProxyInfo.Windows.cs" Condition=" '$(TargetsWindows)' == 'true' and $([MSBuild]::IsTargetFrameworkCompatible('$(TargetFramework)', '$(NetCoreAppCurrent)'))"
              Link="ProductionCode\System\Net\Http\SocketsHttpHandler\SystemProxyInfo.Windows.cs" />
     <Compile Include="..\..\src\System\Net\Http\HttpUtilities.AnyOS.cs"
              Link="ProductionCode\System\Net\Http\HttpUtilities.AnyOS.cs" />
@@ -259,7 +259,7 @@
     <Compile Include="DigestAuthenticationTests.cs" />
     <Compile Include="Fakes\HttpClientHandler.cs" />
     <Compile Include="Fakes\HttpTelemetry.cs" />
-    <Compile Include="Fakes\MacProxy.cs" Condition=" ('$(TargetsOSX)' == 'true' or '$(TargetsiOS)' == 'true' or '$(TargetstvOS)' == 'true') and '$(TargetFramework)' == '$(NetCoreAppCurrent)'" />
+    <Compile Include="Fakes\MacProxy.cs" Condition=" ('$(TargetsOSX)' == 'true' or '$(TargetsiOS)' == 'true' or '$(TargetstvOS)' == 'true') and $([MSBuild]::IsTargetFrameworkCompatible('$(TargetFramework)', '$(NetCoreAppCurrent)'))" />
     <Compile Include="Headers\AltSvcHeaderParserTest.cs" />
     <Compile Include="Headers\AuthenticationHeaderValueTest.cs" />
     <Compile Include="Headers\ByteArrayHeaderParserTest.cs" />
diff --git a/src/libraries/System.Text.Encoding.CodePages/src/System.Text.Encoding.CodePages.csproj b/src/libraries/System.Text.Encoding.CodePages/src/System.Text.Encoding.CodePages.csproj
index 4f2826bd93ee55..375255d3883514 100644
--- a/src/libraries/System.Text.Encoding.CodePages/src/System.Text.Encoding.CodePages.csproj
+++ b/src/libraries/System.Text.Encoding.CodePages/src/System.Text.Encoding.CodePages.csproj
@@ -55,10 +55,10 @@
   <ItemGroup Condition="$(TargetFramework.StartsWith('netstandard')) and '$(TargetsWindows)' != 'true' ">
     <Compile Include="System\Text\CodePagesEncodingProvider.Default.cs" />
   </ItemGroup>
-  <ItemGroup Condition="'$(TargetFramework)' == '$(NetCoreAppCurrent)' and '$(TargetsWindows)' != 'true' ">
+  <ItemGroup Condition="$([MSBuild]::IsTargetFrameworkCompatible('$(TargetFramework)', '$(NetCoreAppCurrent)')) and '$(TargetsWindows)' != 'true' ">
     <Compile Include="System\Text\CodePagesEncodingProvider.Default.cs" />
   </ItemGroup>
-  <ItemGroup Condition="'$(TargetFramework)' == '$(NetCoreAppCurrent)'">
+  <ItemGroup Condition="$([MSBuild]::IsTargetFrameworkCompatible('$(TargetFramework)', '$(NetCoreAppCurrent)'))">
     <Compile Include="System\Text\CodePagesEncodingProvider.netcoreapp.cs" />
     <Compile Include="System\Text\BaseCodePageEncoding.netcoreapp.cs" />
   </ItemGroup>