diff --git a/src/coreclr/interpreter/compiler.cpp b/src/coreclr/interpreter/compiler.cpp
index f0c58a89abc193..9289dd8eb747c5 100644
--- a/src/coreclr/interpreter/compiler.cpp
+++ b/src/coreclr/interpreter/compiler.cpp
@@ -6460,7 +6460,19 @@ void InterpCompiler::UpdateLocalIntervalMaps()
         int32_t varIndex = suspendData->returnValueVarStackOffset;
         if (varIndex != -1)
         {
-            suspendData->returnValueVarStackOffset = m_pVars[varIndex].offset;
+            assert(!m_pVars[varIndex].global);
+            if (m_pVars[varIndex].liveStart == m_pVars[varIndex].liveEnd)
+            {
+                // The return result of the async call is not used by the method, so the allocated
+                // stack offset will be immediately reused by any vars that become live. Keep the
+                // continuation layout unchanged, but mark the return value stack offset as invalid
+                // so resume skips copying the stored result back to the interpreter stack.
+                suspendData->returnValueVarStackOffset = -1;
+            }
+            else
+            {
+                suspendData->returnValueVarStackOffset = m_pVars[varIndex].offset;
+            }
         }
     }
 }
diff --git a/src/coreclr/vm/interpexec.cpp b/src/coreclr/vm/interpexec.cpp
index a8b24b9a4de456..95151d38cdfd3a 100644
--- a/src/coreclr/vm/interpexec.cpp
+++ b/src/coreclr/vm/interpexec.cpp
@@ -4581,7 +4581,7 @@ do                                                                      \
 
                     // Explicitly copy the return value from the continuation's result storage
                     // to the interpreter stack.
-                    if (pAsyncSuspendData->returnValueContinuationDataSize > 0)
+                    if (pAsyncSuspendData->returnValueVarStackOffset != -1)
                     {
                         memcpy(LOCAL_VAR_ADDR(pAsyncSuspendData->returnValueVarStackOffset, uint8_t),
                                continuation->GetResultStorage(),