diff --git a/src/coreclr/gc/gcpriv.h b/src/coreclr/gc/gcpriv.h
index 519597c38ea9e0..8ec1f84c72fe5b 100644
--- a/src/coreclr/gc/gcpriv.h
+++ b/src/coreclr/gc/gcpriv.h
@@ -140,13 +140,15 @@ inline void FATAL_GC_ERROR()
 //
 // This means any empty regions can be freely used for any generation. For
 // Server GC we will balance regions between heaps.
-// For now disable regions for standalone GC and macOS builds
+// For now disable regions for standalone GC builds
 // For SunOS or illumos this is temporary, until we can add MAP_PRIVATE
 // to the mmap() calls in unix/gcenv.unix.cpp  More details here:
 //    https://github.com/dotnet/runtime/issues/104211
-#if defined (HOST_64BIT) && !defined (BUILD_AS_STANDALONE) && !defined(__APPLE__) && !defined(__sun)
+// Apple non-macOS platforms (such as iOS, tvOS, and Mac Catalyst) disallow
+// the large virtual address space reservations that GC regions require.
+#if defined (HOST_64BIT) && !defined (BUILD_AS_STANDALONE) && !defined(__sun) && (!defined(HOST_APPLE) || defined(HOST_OSX))
 #define USE_REGIONS
-#endif //HOST_64BIT && BUILD_AS_STANDALONE && !__APPLE__
+#endif //HOST_64BIT && !BUILD_AS_STANDALONE && !__sun && (!HOST_APPLE || HOST_OSX)
 
 //#define SPINLOCK_HISTORY
 //#define RECORD_LOH_STATE