diff --git a/src/Components/WebView/WebView/src/IpcReceiver.cs b/src/Components/WebView/WebView/src/IpcReceiver.cs
index a1cb04e0893e..26d0e89a6ae1 100644
--- a/src/Components/WebView/WebView/src/IpcReceiver.cs
+++ b/src/Components/WebView/WebView/src/IpcReceiver.cs
@@ -46,6 +46,13 @@ public async Task OnMessageReceivedAsync(PageContext pageContext, string message
                 throw new InvalidOperationException("Cannot receive IPC messages when no page is attached");
             }
 
+            // If the page context's JS runtime has been disposed, ignore messages
+            // for the old page since they would target stale JS object references.
+            if (pageContext.JSRuntime.IsDisposed)
+            {
+                return;
+            }
+
             switch (messageType)
             {
                 case IpcCommon.IncomingMessageType.BeginInvokeDotNet:
diff --git a/src/Components/WebView/WebView/src/PageContext.cs b/src/Components/WebView/WebView/src/PageContext.cs
index 9b198fb8d0df..0dc8b1fee180 100644
--- a/src/Components/WebView/WebView/src/PageContext.cs
+++ b/src/Components/WebView/WebView/src/PageContext.cs
@@ -54,6 +54,12 @@ public PageContext(
 
     public async ValueTask DisposeAsync()
     {
+        // Prevent any further JS interop calls before disposing the renderer.
+        // This ensures components that invoke JS in their DisposeAsync see
+        // JSDisconnectedException instead of sending stale calls to the page.
+        // Matches the pattern used by CircuitHost.DisposeAsync for Blazor Server.
+        JSRuntime.MarkAsDisconnected();
+
         await Renderer.DisposeAsync();
         await _serviceScope.DisposeAsync();
     }
diff --git a/src/Components/WebView/WebView/src/Services/WebViewJSRuntime.cs b/src/Components/WebView/WebView/src/Services/WebViewJSRuntime.cs
index 7295575068cf..df9984f0679c 100644
--- a/src/Components/WebView/WebView/src/Services/WebViewJSRuntime.cs
+++ b/src/Components/WebView/WebView/src/Services/WebViewJSRuntime.cs
@@ -10,9 +10,12 @@ namespace Microsoft.AspNetCore.Components.WebView.Services;
 internal sealed class WebViewJSRuntime : JSRuntime
 {
     private IpcSender _ipcSender;
+    private bool _isDisposed;
 
     public ElementReferenceContext ElementReferenceContext { get; }
 
+    internal bool IsDisposed => _isDisposed;
+
     public WebViewJSRuntime()
     {
         ElementReferenceContext = new WebElementReferenceContext(this);
@@ -26,6 +29,11 @@ public void AttachToWebView(IpcSender ipcSender)
         _ipcSender = ipcSender;
     }
 
+    internal void MarkAsDisconnected()
+    {
+        _isDisposed = true;
+    }
+
     public JsonSerializerOptions ReadJsonSerializerOptions() => JsonSerializerOptions;
 
     protected override void BeginInvokeJS(long taskId, string identifier, string argsJson, JSCallResultType resultType, long targetInstanceId)
@@ -45,6 +53,8 @@ protected override void BeginInvokeJS(long taskId, string identifier, string arg
 
     protected override void BeginInvokeJS(in JSInvocationInfo invocationInfo)
     {
+        ThrowIfDisposed();
+
         if (_ipcSender is null)
         {
             throw new InvalidOperationException("Cannot invoke JavaScript outside of a WebView context.");
@@ -55,6 +65,11 @@ protected override void BeginInvokeJS(in JSInvocationInfo invocationInfo)
 
     protected override void EndInvokeDotNet(DotNetInvocationInfo invocationInfo, in DotNetInvocationResult invocationResult)
     {
+        if (_isDisposed)
+        {
+            return;
+        }
+
         var resultJsonOrErrorMessage = invocationResult.Success
             ? invocationResult.ResultJson
             : invocationResult.Exception.ToString();
@@ -63,6 +78,11 @@ protected override void EndInvokeDotNet(DotNetInvocationInfo invocationInfo, in
 
     protected override void SendByteArray(int id, byte[] data)
     {
+        if (_isDisposed)
+        {
+            return;
+        }
+
         _ipcSender.SendByteArray(id, data);
     }
 
@@ -73,4 +93,14 @@ protected override Task TransmitStreamAsync(long streamId, DotNetStreamReference
     {
         return TransmitDataStreamToJS.TransmitStreamAsync(this, "Blazor._internal.receiveWebViewDotNetDataStream", streamId, dotNetStreamReference);
     }
+
+    private void ThrowIfDisposed()
+    {
+        if (_isDisposed)
+        {
+            throw new JSDisconnectedException(
+                "JavaScript interop calls cannot be issued at this time. This is because the WebView page has been " +
+                "disposed.");
+        }
+    }
 }
diff --git a/src/Components/WebView/WebView/test/WebViewManagerTests.cs b/src/Components/WebView/WebView/test/WebViewManagerTests.cs
index 4a76b94073ca..88ac6758604e 100644
--- a/src/Components/WebView/WebView/test/WebViewManagerTests.cs
+++ b/src/Components/WebView/WebView/test/WebViewManagerTests.cs
@@ -2,6 +2,7 @@
 // The .NET Foundation licenses this file to you under the MIT license.
 
 using Microsoft.Extensions.DependencyInjection;
+using Microsoft.JSInterop;
 
 namespace Microsoft.AspNetCore.Components.WebView;
 
@@ -110,6 +111,26 @@ public async Task AddRootComponentsWithExistingSelector_Throws()
         Assert.Equal($"There is already a root component with selector '{arbitraryComponentSelector}'.", ex.Message);
     }
 
+    [Fact]
+    public async Task AttachingToNewPage_ThrowsJSDisconnectedExceptionDuringComponentDispose()
+    {
+        var services = RegisterTestServices().AddTestBlazorWebView().BuildServiceProvider();
+        var fileProvider = new TestFileProvider();
+        var webViewManager = new TestWebViewManager(services, fileProvider);
+        await webViewManager.AddRootComponentAsync(typeof(PerformJSInteropOnDisposeComponent), "#app", ParameterView.Empty);
+
+        webViewManager.ReceiveAttachPageMessage();
+
+        // Simulate a page reload which disposes the old PageContext (including renderer)
+        // and creates a new one. Components with IAsyncDisposable that call JS interop
+        // should see JSDisconnectedException.
+        webViewManager.ReceiveAttachPageMessage();
+
+        var singleton = services.GetRequiredService<SingletonService>();
+        Assert.Single(singleton.DisposedComponentExceptions);
+        Assert.IsType<JSDisconnectedException>(singleton.DisposedComponentExceptions[0]);
+    }
+
     private static IServiceCollection RegisterTestServices()
     {
         return new ServiceCollection().AddSingleton<SingletonService>().AddScoped<ScopedService>();
@@ -166,6 +187,7 @@ public Task SetParametersAsync(ParameterView parameters)
     private class SingletonService
     {
         public List<ScopedService> Services { get; } = new();
+        public List<Exception> DisposedComponentExceptions { get; } = new();
 
         public void Add(ScopedService service)
         {
@@ -192,4 +214,41 @@ public class AsyncDisposableService : IAsyncDisposable
     {
         public ValueTask DisposeAsync() => ValueTask.CompletedTask;
     }
+
+    private class PerformJSInteropOnDisposeComponent : IComponent, IAsyncDisposable
+    {
+        private RenderHandle _handle;
+
+        [Inject] public IJSRuntime JSRuntime { get; set; } = default!;
+        [Inject] public SingletonService Singleton { get; set; } = default!;
+
+        public void Attach(RenderHandle renderHandle)
+        {
+            _handle = renderHandle;
+        }
+
+        public Task SetParametersAsync(ParameterView parameters)
+        {
+            _handle.Render(builder =>
+            {
+                builder.OpenElement(0, "p");
+                builder.AddContent(1, "Hello world!");
+                builder.CloseElement();
+            });
+
+            return Task.CompletedTask;
+        }
+
+        public async ValueTask DisposeAsync()
+        {
+            try
+            {
+                await JSRuntime.InvokeVoidAsync("SomeJsCleanupCode");
+            }
+            catch (Exception ex)
+            {
+                Singleton.DisposedComponentExceptions.Add(ex);
+            }
+        }
+    }
 }