diff --git a/monai/utils/misc.py b/monai/utils/misc.py
index 022cd2c58a..1c79562f07 100644
--- a/monai/utils/misc.py
+++ b/monai/utils/misc.py
@@ -239,6 +239,13 @@ def set_determinism(
         use_deterministic_algorithms: Set whether PyTorch operations must use "deterministic" algorithms.
         additional_settings: additional settings that need to set random seed.
 
+    Note:
+
+        This function will not affect the randomizable objects in :py:class:`monai.transforms.Randomizable`, which
+        have independent random states. For those objects, the ``set_random_state()`` method should be used to
+        ensure the deterministic behavior (alternatively, :py:class:`monai.data.DataLoader` by default sets the seeds
+        according to the global random state, please see also: :py:class:`monai.data.utils.worker_init_fn` and
+        :py:class:`monai.data.utils.set_rnd`).
     """
     if seed is None:
         # cast to 32 bit seed for CUDA