diff --git a/cuda_core/cuda/core/checkpoint.py b/cuda_core/cuda/core/checkpoint.py
index 7f811013d1..a648911678 100644
--- a/cuda_core/cuda/core/checkpoint.py
+++ b/cuda_core/cuda/core/checkpoint.py
@@ -239,14 +239,21 @@ def _as_cuuuid(driver, value, buffers):
     the ``"xxxxxxxx-xxxx-xxxx-xxxx-xxxxxxxxxxxx"`` format returned by
     :attr:`Device.uuid`.
     """
+    if isinstance(value, driver.CUuuid):
+        return value
     if isinstance(value, str):
-        raw = bytes.fromhex(value.replace("-", ""))
+        try:
+            raw = bytes.fromhex(value.replace("-", ""))
+        except ValueError:
+            raise ValueError(
+                f"GPU UUID string must be 32 hex characters (with optional hyphens), got {value!r}"
+            ) from None
         if len(raw) != 16:
             raise ValueError(f"GPU UUID string must be 32 hex characters (with optional hyphens), got {value!r}")
         buf = _ctypes.create_string_buffer(raw, 16)
         buffers.append(buf)
         return driver.CUuuid(_ctypes.addressof(buf))
-    return value
+    raise TypeError("GPU UUID values must be CUDA UUID objects or UUID strings")
 
 
 __all__ = [